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Abstract
Background: To study the histomorphological
changes in placentae of pre-eclamptic mothers and to
compare them with placentae of normotensive
mothers.
Methods: In this comparative study, hundred
placentae were taken and divided into two groups.
Normotensive group included placentae from
mothers having normal blood pressure and
hypertensive group included placentae from mothers
having pre-eclampsia. Placentae were fixed in
normal saline for 48 hours. After fixation the
placentae were divided into four quadrants and 5mm
tissue was taken from the center of upper right and
lower left quadrants. After tissue processing and
staining, the histomorphological changes were
studied in both normotensive and hypertensive
groups.
Results: The number of terminal villi were
increased in hypertensive group. The quantitative
difference between number of syncytial knots and
villous membrane thickness in normotensive and
hypertensive groups was statistically significant .
Conclusion: Increased number of syncytial knots
was observed along with increased thickness of
vasculosyncytial membrane in hypertensive group as
compared to normotensive group that may be the
cause or effect of placental hypoxia