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Abstract
Background: To study the histomorphological effects
of Mifepristone treatment on rat uterus.
Methods: In this experimental study, sixty adult female
rats were divided randomly into two groups, comprising of
30 animals in each group. In group A one ml of normal
saline was given orally daily for three months while in
group B mifepristone was given orally in a dose of 1 mg/kg
body weight daily for three months. All the animals were
sacrificed next day after the last oral dose. Two ml blood
was taken directly from the heart for measurement of
estrogen and progesterone levels. About ½ cm piece of
tissue was taken from the middle of the right uterine horn.
Sections were cut and immunohistochemical staining
procedure was done for demonstration of progesterone
and estrogen receptors
Results: In the experimental group the number of
progesterone and estrogen receptors in the uterine
myometrium of the experimental group were decreased
and found statistically significant. Significantly lower
level of progesterone while higher levels of estrogen level
were noted in the experimental group as compared to
control group. In the experimental group thickness of the
myometrium was reduced
Conclusion: Long term mifepristone (Antiprogesterogen)
administration suppresses the endometrial
proliferation. It decreases the number of progesterone and
estrogen receptors. It lowers the serum levels of
progesterone, while estrogen levels elevates it.