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Abstract
Background : To study the effect of routine antenatal
daily iron supplementation on gross morphology of
placenta.
Methods: In this randomized control trial thirty two
adult female and ten adult male Sprague- Dawley rats
(weighing 200-250 gm) were taken. They were distributed
randomly into two equal study groups. Ferrous sulphate
was administered orally at 0 and 10mg/kg/day starting
from gestation day (GD) 0, and half of the animals were
sacrificed on GD 17 and half were sacrificed on GD 20.
Placentae were removed and morphometric study was
done for both qualitative and quantitative parameters.
Results: The results were assessed on GD 17 and 20.
There was no significant change in placental weight,
diameter and thickness on GD 17 between the two groups.
There was significant increase in placental weight,
diameter and thickness on GD 20 in non-supplemented
(control) rats as compared to iron replete rats.
Conclusion: Antenatal daily iron supplementation is
effective to prevent anaemia and iron deficiency.