@article{Kashif Rauf, Tehmina Qamar,Bashir Ahmad, Shoaib Malik, Nadeem Naseem, Naseer ud Din_2019, title={Effects on ALT normalization in the first month of treatment by Sofosbuvir/Ribavirin therapy versus Sofosbuvir/Daclatasvir therapy in HCV infected individuals}, volume={23}, url={http://journalrmc.com/index.php/JRMC/article/view/1295}, abstractNote={<p><strong>Objective</strong>: To evaluate the effects on ALT normalization in first month by SOFOS/RIB therapy versus SOFOS/DAC therapy in HCV infected individuals in Pakistan</p> <p><strong>Study Design</strong>: Cross sectional comparative study</p> <p><strong>Material and Methods</strong>: In a cross sectional analysis in a total of 200 Hepatitis c infected patients, sex, H/O diabetes mellitus, prior interferon therapy, decrease in hemoglobin >2 gm/dl in 1st month and rise in serum bilirubin in 1st month were the qualitative variables and the quantitative variables were age, weight, baseline hemoglobin, baseline bilirubin at week 4 of treatment. The statistical relation of the mentioned variables was checked using SPSS version 15 on the basis of data collected.</p> <p><strong>Results</strong>: Out of total 200 patients, 47% (94) were males, 53% (106) were females, 28% (56) patients were diabetic & 44.5% (89) patients had history of prior interferon therapy, 28.5% (57) patients were having low hemoglobin levels before starting above mentioned treatment. Both the groups completed the treatments A & B for 24 &12 weeks respectively & collected data showed the superiority of treatment B to treatment A as no decrease in hemoglobin (p=0.000), & no rise in serum bilirubin(p=0.000) during 1st month of treatment while ,serum bilirubin was 93 % in treatment B and 73 % in treatment A.</p> <p><strong>Conclusion</strong>: The results concluded that treatment B (Sofosbuvir / Daclatasvir for 12 weeks) is superior anti hepatitis C therapy as compared to the treatment A (Sofosbuvir / Ribavirin for 24 weeks) in order to achieve ALT normalization in first month of therapy in Pakistani population. Ribavirin should be avoided to prevent hemolytic anemia as well.</p> <p><strong>Keywords</strong>: Hepatitis C, Alkaline Phosphatase</p>}, number={4}, journal={Journal of Rawalpindi Medical College}, author={Kashif Rauf, Tehmina Qamar,Bashir Ahmad, Shoaib Malik, Nadeem Naseem, Naseer ud Din, Kashif Rauf, Tehmina Qamar,Bashir Ahmad, Shoaib Malik, Nadeem Naseem, Naseer ud Din}, year={2019}, month={Dec.} }