TY - JOUR AU - Ambreen Zahoor, Iram Iqbal, Sajid Naseem, Zaidan Idrees Choudhary, Ambreen Zahoor, Iram Iqbal, Sajid Naseem, Zaidan Idrees Choudhary PY - 2020/12/30 Y2 - 2024/03/28 TI - Association of Lipid Profile with Non-Alcoholic Fatty Liver Disease diagnosed on Ultrasound JF - Journal of Rawalpindi Medical College JA - JRMC VL - 24 IS - 4 SE - Articles DO - 10.37939/jrmc.v24i4.1398 UR - http://journalrmc.com/index.php/JRMC/article/view/1398 SP - AB - <p><strong>Objectives:</strong> To evaluate lipid profile parameters in patients with various grades of non-alcoholic fatty liver disease (NAFLD) diagnosed on sonography.&nbsp;</p><p><strong>Material and Method:</strong> This descriptive cross-sectional study was conducted at HBS General Hospital, Islamabad over a period of six months from January 2018 to June 2018. Seventy-nine adults of either gender diagnosed with NAFLD on ultrasonography were consecutively included. Fasting blood sample of all the subjects was analyzed for total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) Comparison of lipid abnormalities between different grades of NAFLD was done by statistical analysis with p-value &lt;0.05 considered statistically significant.</p><p><strong>Results:</strong> Out of the total 79 patients, grade I, II, and III NAFLD was diagnosed in 56.6%, 45.5%, and 3.9% respectively. Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) were raised in 28 (35.4%), 43 (54.4%) and 43 (54.4%) patients respectively. Low serum high-density lipoprotein cholesterol (HDL-C) levels were seen in 74 (93.6%) of patients. Statistical analysis showed a significant increase in frequency as well as mean values in all serum lipid profile parameters with the severity of NAFLD grades except total cholesterol (TC).</p><p><strong>Conclusion:</strong> Increasing grades of NAFLD showed a significant correlation with higher levels of cholesterol, LDL, and decreasing levels of HDL, which are all associated with cardiovascular problems.</p> ER -