TY - JOUR AU - Fauzia Qureshi , Shahnila Nadir , Nida Qasim Hayat , Maryam Ashraf , Fauzia Qureshi , Shahnila Nadir , Nida Qasim Hayat , Maryam Ashraf PY - 2017/12/30 Y2 - 2024/03/28 TI - Histological Effects of Letrozole and Clomiphene Citrate on Albino Rat Ovary after Consecutive 1-4 Estrous Cycles JF - Journal of Rawalpindi Medical College JA - JRMC VL - 21 IS - 4 SE - Articles DO - UR - http://journalrmc.com/index.php/JRMC/article/view/819 SP - AB - <p><strong>Background</strong><strong>:To observe the histological effects of letrozole and Clomiphene citrate on albino rat&nbsp; ovary after consecutive 1-4 estrous cycles.</strong></p><p><strong>Methods</strong><strong>: An experimental study was carried out on eighty four adult female Albino rats. The rats were equally divided into three groups. Vaginal smear cytology was performed to determine the phases of estrous cycle. The group A&nbsp; was given normal saline orally and served as control. Group B&nbsp; was given letrozole(Femara) at dose 5mg/kg orally and group C&nbsp; was&nbsp; given clomiphene citrate at dose 100ug/kg orally.&nbsp; Each group was further subdivided into four subgroups on the basis of&nbsp; duration of treatment. Ovarian sections&nbsp; were made and stained with Haematoxylin and Eosin.&nbsp; Number of antral follicle&nbsp; in both ovaries&nbsp; of each subgroups&nbsp; were counted and were analyzed using SPSS 20.0. Mean ± S.D. </strong></p><p><strong>Results</strong><strong>: Morphometric and statistical analysis revealed that number of antral follicle&nbsp;&nbsp; was significantly increased with&nbsp; both letrozole&nbsp; and&nbsp; clomiphene citrate as compared to control. However&nbsp; marked increase in&nbsp; number&nbsp; of antral follicle and development of cystic follicles was observed in clomiphene citrate group.</strong></p><p><strong>Conclusion: Letrozole and&nbsp; clomiphene citrate&nbsp; both have improved folliculogenesis. However letrozole is more effective and safe for ovulation induction</strong></p> ER -