Keywords
Betahistine
Gingko biloba extract
Ginbex
Comparative study
Patient satisfaction
Adverse effects
Chronic Dizziness
How to Cite
Abstract
Objective: Vertigo significantly impairs balance and quality of life. Betahistine and standardized Ginkgo biloba extract (Ginbex) are commonly used treatments, but comparative data remain limited. This study compared the efficacy, safety, adherence, and patient satisfaction of these treatments in patients with chronic vertigo.
Methods: This prospective comparative study was conducted at the ENT Department of Benazir Bhutto Hospital. One hundred patients with chronic peripheral vertigo were allocated to Ginbex (n=50) or betahistine (n=50) for 12 weeks. Outcomes included Vertigo Symptom Scale–Vertigo (VSS-V), Vertigo Symptom Scale–Anxiety (VSS-A), Clinical Global Impression scores, adherence, adverse effects, and patient satisfaction. Statistical analysis was performed using SPSS version 26.
Results: Both groups showed significant improvement in vertigo severity and anxiety symptoms after treatment (p<0.001). No significant between-group differences were observed for VSS-V (p=0.334), VSS-A (p=0.825), or CGI change (p=0.151). Adverse effects were significantly lower with Ginbex (12%) than betahistine (40%) (p=0.001). Patient satisfaction was higher in the Ginbex group (4.76±0.43 vs. 3.62±0.97, p<0.001). Adherence was slightly higher with betahistine but not statistically significant (p=0.061).
Conclusion: Ginbex and betahistine demonstrated comparable efficacy in chronic vertigo. Ginbex showed better tolerability and higher patient satisfaction, suggesting it may be a useful alternative in selected patients.
Keywords: Vertigo, Betahistine, Ginkgo biloba extract, Ginbex, Comparative study, Patient satisfaction, Adverse effects, Chronic dizziness.
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