@article{Naureen Chaudhri , Mirza Naveed Shehzad, Mamoon Akbar Qureshi, Mariam Masud_2019, title={Spectrum of Acute Kidney Injury in a Nephrology Unit}, volume={23}, url={https://journalrmc.com/index.php/JRMC/article/view/1086}, abstractNote={<p>Background: To identify etiologic factors causing <br>acute kidney injury (AKI) in our local population that <br>were admitted to tertiary care nephrology unit over one <br>year duration. <br>Methods: In this prospective cohort study adult <br>patients with elevated serum creatinine, evaluated at least <br>twice,were included. Workup for glomerulonephritis <br>included complements levels, ANA, Anti dsDNA, <br>ANCA,AntiGBM, SPEP. Renal biopsy was performed for <br>suspected RPGN/Vasculitis, AIN, unexplained AKI.Renal <br>replacement therapy was initiated for standard <br>indications. Decreased renal perfusion was diagnosed <br>when blood pressure was less than 90/60 mmHg, signs of <br>volume depletion and severe cardiac failure. Urine output <br> less than 400ml/day was taken as oliguria. The AKI <br>definition and diagnosis was based on RILFE criteria ,i.e, <br>an abrupt (1 to 7 days) and sustained (more than 24 hours) <br>decrease in kidney function. <br>Results: Majority (62%) were male. Majority of the <br>patients (87.1%) were in failure category. Infection/sepsis <br>was the most common etiology (44.6 %), followed by drugs <br>(10.5%),gastroenteritis (10.2%),surgical cases (8.8%) and <br>obstructive nephropathy (7.5 %). Mortality was 39.1%, <br>reflecting critical condition and markedly deranged renal <br>function. <br>Conclusion: AKI is a major public health challenge. It <br>is associated with high morbidity and mortality. <br>Infection/sepsis is the predominant etiological factor <br>causing AKI in our patients. Combating <br>infections/communicable diseases is crucial in preventing <br>AKI</p>}, number={1}, journal={Journal of Rawalpindi Medical College}, author={Naureen Chaudhri , Mirza Naveed Shehzad, Mamoon Akbar Qureshi, Mariam Masud, Naureen Chaudhri , Mirza Naveed Shehzad, Mamoon Akbar Qureshi, Mariam Masud}, year={2019}, month={May} }