@article{Mehvish Ashfaq , Kamil Asghar Imam , Bushra Riaz_2017, title={Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats}, volume={21}, url={https://journalrmc.com/index.php/JRMC/article/view/817}, abstractNote={<p> </p> <p><strong>Background:</strong><strong> To evaluate the effects of type 2 diabetes mellitus on fatigability of soleus (slow) and extensor digitorium longus (EDL) (fast) muscles of female Sprague Dawley rats.</strong></p> <p><strong>Methods</strong><strong>:</strong><strong>Twenty healthy female Sprague Dawley rats were divided into 2 groups with 10 rats each. Group I (control) was fed with normal diet and group II (diabetic) was given high fat diet. Group II was given intra-peritoneal streptozotocin(STZ) (35mg/kg body weight) on 15<sup>th</sup> day. Body weight, blood glucose and TG:HDL ratio were estimated on 21<sup>st</sup> day to confirm type 2 diabetes mellitus (T2DM) induction. Soleus and extensor digitorium longus (EDL) muscles were removed intact and fixed in organ bath system containing Krebs-Ringer buffer solution and connected to data acquisition unit (iWorx<sup>®</sup>) to study their contractile and fatigability parameters.</strong></p> <p><strong>Results:</strong><strong> Soleus and extensor digotorium longus muscles of female diabetic rats displayed significantly (p<0.05) increased fatigability.</strong></p> <p><strong>Conclusions:Fatigability of slow (soleus) and fast (EDL) muscles increases in T2DM.There occurs reduction in resistance to and recovery from fatigue in both slow and fast skeletal muscles of type 2 diabetic female Sprague Dawley rats</strong></p>}, number={4}, journal={Journal of Rawalpindi Medical College}, author={Mehvish Ashfaq , Kamil Asghar Imam , Bushra Riaz, Mehvish Ashfaq , Kamil Asghar Imam , Bushra Riaz}, year={2017}, month={Dec.} }