TY - JOUR AU - Shamila Tahir,Nazish Mazari,Aisha Chauhdry,Ghulam Mustafa, Shabbir Hussain,Faheem Shahzad, Shahida Mohsin, Shamila Tahir,Nazish Mazari,Aisha Chauhdry,Ghulam Mustafa, Shabbir Hussain,Faheem Shahzad, Shahida Mohsin PY - 2019/05/02 Y2 - 2024/03/28 TI - Comparison of levels of von Willebrand factor and ADAMTS13 in Patients of Myocardial Infarction and Healthy Controls JF - Journal of Rawalpindi Medical College JA - JRMC VL - 23 IS - 1 SE - Articles DO - UR - https://journalrmc.com/index.php/JRMC/article/view/1087 SP - AB - <p>Background: to determine the levels of von <br>Willebrand factor (vWF) and ADAMTS13 in patients <br>of myocardial infarction and healthy controls <br>Methods: In a comparative study, the samples were <br>collected from 45 myocardial infarction patients and <br>45 age and sex matched healthy controls. Total 5ml <br>blood was collected in tri-sodium citrated vials. The <br>determination of VWF was carried out by <br>chromogenic assay on Stago and ADAMTS13 assay <br>was carried out by standard ELISA kit. The Mann <br>Whitney U test was used to determine the median <br>difference between two groups (patients and <br>control). <br>Results; Patients with MI had higher median <br>plasma level of VWF (161%) as compared to healthy <br>controls (120%). The median plasma level of <br>ADAMTS13 of control and patients was 56.54 U/L <br>and 18.80 U/L respectively. The difference in median <br>plasma levels of VWF &amp; ADAMTS13 between <br>groups was statistically significant (p &lt; 0.001 <br>Conclusion: Plasma VWF and ADAMTS13 had a <br>significant association with MI patients. There exists <br>an inverse correlation between plasma VWF and <br>ADAMTS13 levels in MI patients, but this <br>correlation was very weak in control group.</p> ER -