TY - JOUR AU -  Latafat Ali Chughtai , Aliza Sahito , Jawaid Ahmed Zai , Zaibunisa Mughal , Jamshed Warsi , Benazir Mahar ,  Latafat Ali Chughtai , Aliza Sahito , Jawaid Ahmed Zai , Zaibunisa Mughal , Jamshed Warsi , Benazir Mahar PY - 2020/09/30 Y2 - 2024/03/28 TI - Assessment of factors responsible for early menopause in Interior Sindh, Pakistan JF - Journal of Rawalpindi Medical College JA - JRMC VL - 24 IS - 3 SE - Articles DO - 10.37939/jrmc.v24i3.1175 UR - https://journalrmc.com/index.php/JRMC/article/view/1175 SP - AB - <p><strong>Objective: </strong>To evaluate the factors leading to the early onset of menopause (&lt;40 years) in the women in the interior of Sindh.</p><p><strong>Materials and Methods: </strong>A cross-sectional study was conducted on 218 individuals among them 109 were postmenopausal women (with premature menopause)&nbsp; and 109 were normal menstruating females during the period of six months from November 2014 to April&nbsp; 2015, data was obtained from Interior Sindh, Larkana, Hyderabad, and Benazirabad.&nbsp; Factors considered were age, number of children, history of the obstetric process (ovarian and uterine), diseases, and premature menopause history in first-cousin marriages. The questionnaire data and blood samples were collected for hormonal assays such as LH,&nbsp; prolactin, and FSH. The hormone levels were analyzed by ELISA method, SPSS version 17 was used for data analysis.</p><p><strong>Results: </strong>&nbsp;Out of 109 subjects the percentage of early menopause due to: anorexia nervosa was 17%, brain tumor 7%, ovarian cancer 6%, hormonal disorders 23%, hysterectomy 15%, oophorectomy 5%, Pituitary gland dysfunction 4%, Sheehan Syndrome 24%, Polycystic Ovarian Syndrome (PCOS) 8%.</p><p><strong>Conclusion:</strong> Early menopause was found related to pathological and psychological factors including brain tumor, ovarian cancer, family history, Anorexia nervosa, and certain surgical interventions.</p> ER -