TY - JOUR AU - Afzal, Erum AU - Sheikh, Muhammad Aslam AU - Bhaba, Sajjad Hussain AU - Ahmed, Tanveer AU - Iqbal, Imran AU - Iqbal, Muhammad Khalid PY - 2023/04/02 Y2 - 2024/03/29 TI - PSYCHOSOCIAL ILLNESS IN CHILDREN WITH THALASSEMIA: A CASE-CONTROL STUDY JF - Journal of Rawalpindi Medical College JA - JRMC VL - 27 IS - 1 SE - Articles DO - 10.37939/jrmc.v27i1.1825 UR - https://journalrmc.com/index.php/JRMC/article/view/1825 SP - AB - <p><strong><span data-contrast="auto">INTRODUCTION: </span></strong><span data-contrast="auto">Thalassemia</span> <span data-contrast="auto">is the most common hemolytic autosomal recessive disorder. Pakistan has significant number of thalassemic children</span><strong><span data-contrast="auto"> .</span></strong><span data-contrast="auto">The children with chronic disorders like thalassemia are prone to develop psychosocial illness including depression, anxiety, intellectual and behavioral issues.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:276}"> </span></p><p><strong><span data-contrast="auto">OBJECTIVE:</span></strong><span data-contrast="auto"> To assess the psychosocial illness in children with thalassemia and to compare these problems in children with and without Thalassemia</span><span data-contrast="auto"> </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:276}"> </span></p><p><strong><span data-contrast="auto">PLACE &amp; DURATION: </span></strong><span data-contrast="auto">The Children’s Hospital and the institute of child health, Multan. From January to September 2021.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:276}"> </span></p><p><strong><span data-contrast="auto">STUDY DESIGN: C</span></strong><span data-contrast="auto">ase-control</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:276}"> </span></p><p><strong><span data-contrast="auto">MATERIAL AND METHOD:</span></strong><span data-contrast="auto">   In this study 50 children with Thalassemia and 50 normal children were enrolled as case &amp; control according to inclusion and exclusion criteria. After approval from institutional ethical committee, detailed history ,Socioeconomic status, educational status of parent and child, age of diagnosis of disease, and whether thalassemia is well controlled or not and complications were noted. A Pediatric Symptom Checklist was used for psychosocial problems in all children. Data was analyzed by using SPSS version 22. Mean and standard deviation for quantitative data, while frequencies and percent for qualitative data was calculated. P-value was calculated by Chi square test. Prevalence ratio (ODDS ratio) with 95%confidence interval of all variables were calculated.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:276}"> </span></p><p><strong><span data-contrast="auto">RESULTS: </span></strong><span data-contrast="none">Out of 100 patients 50 were in case group (Thalassemia) and 50 control (non-thalassemic.Male female ratio was 1.2:1. 60 %( n=30) cases, 78 %( n=39) control patients were age ranges between 5 to 10 years. Educational level of parents of</span><span data-contrast="auto"> 40%(n=20),and 56%(n=28) was below matric,42%(n=21) and 90%(n=45) patients were going to school in case and control group respectively.82%(n=41) patients belonged to low socioeconomical status in each group. Regarding characteristics of thalassemia 74 %( n=37) patients were diagnosed within 1</span><span data-contrast="auto">st</span><span data-contrast="auto"> year of life, while 26 %( n=13) after 1</span><span data-contrast="auto">st</span><span data-contrast="auto"> year.64 %( n=32) had well controlled and 36 %( n=18) poor controlled disease. 20%(n=10) had developed Diabetes mellitus,2%(n=1) heart failure,74%(37) growth failure,76%(n=38) hemolytic facial features and 72%(n=36)skin discoloration. Psychosocial problems were statistically significant in children with Thalassemia as compared to healthy ones (p-value&lt;0.001).Poorly controlled thalassemia and complications of heart and growth failure were found statistically significant risk factors.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:276}"> </span></p><p><strong><span data-contrast="auto">CONCLUSION:</span></strong><span data-contrast="auto"> Psychosocial problems are common in children with thalassemia as compared to healthy ones.</span><span data-contrast="auto"> So </span><span data-contrast="auto">these patients must be referred for detailed psychological evaluation and management along with medical treatment.</span><span data-ccp-props="{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:0,&quot;335559739&quot;:150,&quot;335559740&quot;:276}"> </span></p> ER -