TY - JOUR AU - Ambreen Aslam, Nighat Sultana, Muhammad Sarwar, Anila Jamil, Fareeha Kausar, Umer Waqar, Ambreen Aslam, Nighat Sultana, Muhammad Sarwar, Anila Jamil, Fareeha Kausar, Umer Waqar PY - 2022/10/27 Y2 - 2024/03/29 TI - Spectrum of Complications in Children with Moderate to Severe DKA Admitted in Pediatric Intensive Care Unit of a Tertiary Care Hospital JF - Journal of Rawalpindi Medical College JA - JRMC VL - 26 IS - 2 SE - Articles DO - 10.37939/jrmc.v26i2.1835 UR - https://journalrmc.com/index.php/JRMC/article/view/1835 SP - AB - <p><strong>Background: </strong>Diabetic Ketoacidosis (DKA) is the major source of mortality and morbidity in type 1 Diabetes Mellitus. Cautious fluid resuscitation, insulin and electrolyte replacement along with observation for complications is the mainstay of treatment. Early identification of complications lead to better management and outcome.</p><p><strong>Objective: </strong>To find out the complications of moderate to severe DKA in pediatric patients admitted in Pediatric Intensive Care Unit (PICU).</p><p><strong>Methods: </strong>Cross-sectional Study was conducted in PICU of University of Child Health Sciences &amp; The Children’s Hospital, Lahore from Jan, 2015 to Dec, 2018.Data was collected from retrospective records of patients admitted in PICU. All patients with moderate/severe DKA were included. Patients with developmental delay were excluded. Data was analyzed using SPSS version 25. Chi-square test was used to find out p-value.</p><p><strong>Results: </strong>A total of 152 patients with moderate/severe DKA were included in the study, having mean age of 7.86 ± 4.06 years. Most patients 42% (n=64) were more than 10 years of age. Mean weight of the children was 19.89 ± 8.70 kg. Majority 59% (n= 89) were of new onset diabetes. Severe DKA was seen in 74% while moderate DKA in 26% patients. The complications seen were: hypokalemia 33% (n=50), cerebral edema 28% (n=42), hypernatremia 18% (n=27), hyponatremia 8% (n=12) and acute kidney injury (AKI) in 7% (n=11). Survival rate was 85% while mortality rate was 15%.</p><p><strong>Conclusion:</strong> Hypokalemia and cerebral edema were the most common complications observed. Complications were more common in those patients who presented with DKA in first presentation.</p><p><strong>Key words: </strong>complications, DKA severity, children, PICU.</p> ER -