Comparison of Oral Azithromycin and Intra Venous Ceftriaxone for Treatment of Uncomplicated Enteric Fever in Children
Background : To compare the clinical efficacy of
intravenous (I/V) Ceftriaxone with oral
Azithromycin in 2-12 year old children diagnosed
with enteric fever.
Methods: In this comparative study children with
the history of fever for >4 days and at least two out
of these findings, i.e., toxic physical appearance,
abdominal pain, coated tongue, hepatomegaly,
splenomegaly were divided into two equal groups.
Patients in Group A were given Azithromycin 20 mg
/ kg/ day as a single oral dose whereas patients in
Group B were given Ceftriaxone 100 mg/kg/day as a
single I/V injection for 07 days. Before initiation of
therapy samples for Typhidot and Widal test were
collected and only those testing positive were
Results: There were 42 (93.3%) and 40 (88.9%)
patients in both the groups respectively who were
clinically cured. No significant difference was found
between these two groups (p-value 0.459).
Conclusion: There was no difference in the
clinical efficacy between Ceftriaxone and
Azithromycin for the treatment of typhoid fever in