Association of Lipid Profile with Non-Alcoholic Fatty Liver Disease diagnosed on Ultrasound

  • Ambreen Zahoor HBS Medical and Dental College
  • Iram ` Iqbal HBS Medical & Dental College, Islamabad
  • Sajid Naseem HBS Medical & Dental College, Islamabad
  • Zaidan Idrees Choudhary HBS Medical & Dental College, Islamabad
Keywords: Non-alcoholic fatty liver disease; Dyslipidemia; Metabolic syndrome.

Abstract

Objectives: To evaluate lipid profile parameters in patients with various grades of non-alcoholic fatty liver disease (NAFLD) diagnosed on sonography. 

Material and Method: This descriptive cross-sectional study was conducted at HBS General Hospital, Islamabad over a period of six months from January 2018 to June 2018. Seventy-nine adults of either gender diagnosed with NAFLD on ultrasonography were consecutively included. Fasting blood sample of all the subjects was analyzed for total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) Comparison of lipid abnormalities between different grades of NAFLD was done by statistical analysis with p-value <0.05 considered statistically significant.

Results: Out of the total 79 patients, grade I, II, and III NAFLD was diagnosed in 56.6%, 45.5%, and 3.9% respectively. Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) were raised in 28 (35.4%), 43 (54.4%) and 43 (54.4%) patients respectively. Low serum high-density lipoprotein cholesterol (HDL-C) levels were seen in 74 (93.6%) of patients. Statistical analysis showed a significant increase in frequency as well as mean values in all serum lipid profile parameters with the severity of NAFLD grades except total cholesterol (TC).

Conclusion: Increasing grades of NAFLD showed a significant correlation with higher levels of cholesterol, LDL, and decreasing levels of HDL, which are all associated with cardiovascular problems.

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Published
2020-12-30
How to Cite
1.
Zahoor A, Iqbal I, Naseem S, Choudhary Z. Association of Lipid Profile with Non-Alcoholic Fatty Liver Disease diagnosed on Ultrasound. JRMC [Internet]. 30Dec.2020 [cited 5Aug.2021];24(4):334-8. Available from: http://journalrmc.com/index.php/JRMC/article/view/1398