Correlation Between Serum Uric Acid, Insulin and Hba1c In Type 2 Diabetes Mellitus

Abstract

Objective: The study aims to determine the relation of serum uric acid levels, glycated haemoglobin A1c (HbA1c) and insulin levels in Type II Diabetes Mellitus as well as their role as potential disease predictors

Method: This cross-sectional study was conducted in the Department of General Medicine, FFH Rawalpindi (Jan-Jul 2020). A total of 160 adults with diagnosed type II diabetes mellitus were included. Blood reports of patients were analyzed for serum uric acid, HbA1c levels and insulin levels. The inclusion and exclusion criteria were strictly followed to control confounders and bias. Data was analyzed by SPSS V 23. Qualitative variables like gender were measured in the form of percentages and frequencies. Means and standard deviations were calculated for quantitative data like age, type II diabetes mellitus duration, weight, serum uric acid, HbA1c and serum insulin levels. Pearson correlation test was used to assess the relationship between serum uric acid & HbA1c levels, and serum uric acid & insulin levels. The data was stratified into the following types of patient groups: a low & high HbA1c level group (<6.5% and >6.5% respectively), and a low & high insulin level group (with 25 mIU/L being the cut-off value) in male and female gender groups. Post stratification relation was calculated. A p-value <0.05 was considered statistically significant. 

Results: Among 160 patients, the mean age was 50.52+13.35 years; there were 59 (36.9%) males and 101(63.1 %) females. There was no significant correlation observed between serum uric acid levels and HbA1c levels concerning gender stratification, as well as, between serum uric acid and HbA1c levels at low & high insulin levels in type II diabetes mellitus.

Conclusion: The study concluded no positive relation between serum uric acid levels, glycated haemoglobin A1c as well as serum insulin levels in type II diabetes mellitus patients.