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Abstract
Background: To study the histologic effects of carbonated drinks on rat kidneys Methods: In this experimental animal study histological changes on rat kidney caused by chronic consumption of carbonated drinks were observed. Thirty adult Wistar rats with average weight of 200g were randomly assigned into three groups, ten per group . Group A and B served as treatment groups while group C served as the control. The rats in group A were administered a randomly selected carbonated drink ad libitum for thirty days. Rats in group B were given ad libitum access to carbonated drink for sixty days and animals in group C were given water. The rats in group A and B were sacrificed in CO2 and Chloroform chamber on day 30 and 60 respectively. The abdominal region was quickly opened and the kidney dissected out and fixed in 10% formal saline. Deparaffinized sections were stained routinely with haematoxylin and eosin (H & E).
Results: H and E stain study revealed glomeruli congestion and inflammatory cell infiltrate in group A specimens. The specimens of group B showed glomeruli congestion along with tubular necrosis and nuclear cell disturbance.
Conclusion: Long term consumption of carbonated drinks adversely affects histology of kidney, and the deterioration of cells increases with increase in the consumption of beverage.