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Abstract
Background: To study the trend in levels of serum creatinine in prehypertensive people for detection of renal dysfunction.
Methods: In this descriptive study a total of 90 apparently healthy subjects with age being 30-55 years and without any other illness were selected .Blood pressure of participants was monitored and categorised into two groups; normotensive group 1 (n-43) and prehypertensive group 2 (n=43). Any volunteer with raised blood sugar was excluded from the study. Average height and weight of all volunteers were calculated. Blood samples were drawn and serum creatinine was analysed of all participants with Jaffe’s procedure. Serum creatinine serum creatinine > 1.4 mg/dl was set as an outcome variable whereas high normal blood pressure levels were taken as the predictor variables in order to find a cross sectional association amongst them. Effects of demographic factors such as age, weight and height were already adjusted so they did not affect the outcome variables.
Results: Mean systolic and diastolic blood pressures in normotensive group were 111.6±3.4 mmHg and 72.93±3.04 mmHg respectively whereas mean systolic blood pressure in prehypertensive group was 122.74±3.05 mmHg and diastolic 82.37±2.66 mmHg respectively (p<0.0001). Frequencies and percentages for serum creatinine above cutoff levels in prehypertensives were 1 and 2.3% respectively whereas below cutoff levels were 42% and 97.7% respectively. Frequencies and percentages below cutoff levels of serum creatinine were 43 and 100% respectively for the normotensive group. Mean values of serum creatinine levels were 0.9521±0.199 mg/dl in prehypertensives which were statistically not higher than the serum creatinine levels of normotensive group 0.9126±0.157 mg/dl (p>0.05).
Conclusion: Negligible difference in serum creatinine concentrates were found amongst prehypertensives and control group