Official publication of Rawalpindi Medical University
Comparison of Vaginal Isosorbide Mononitrate with Prostaglandin E2 for Pre-Induction Cervical Ripening at Term
PDF

How to Cite

1.
Ayesha Mukhtar, Farzana Kazmi, Farah Rehana. Comparison of Vaginal Isosorbide Mononitrate with Prostaglandin E2 for Pre-Induction Cervical Ripening at Term. JRMC [Internet]. 2013 Jun. 30 [cited 2024 Mar. 28];17(1). Available from: http://journalrmc.com/index.php/JRMC/article/view/527

Abstract

Background : To compare the efficacy of nitric oxide donor isosorbide mononitrate (IMN) with prostaglandin E2 (PGE2) on the cervical ripening and induction of labour at term.
Methods: In this descriptive study sixty patients were divided into two equal groups.Group A consisted of 30 patients to whom Prostaglandin E2 was given. Group B included 30 patients to whom isosorbide mononitrate was given. Three mg of prostaglandin E2 was placed in posterior vaginal fornix in group A patients and dose was repeated every six hours up to 2 doses. 40 mg of isosorbide mononitrate (Monis) was given vaginally in group B patients and dose was repeated every four hour up to 2 doses. During this procedure intermittent fetal heart rate and uterine contraction was noted. Time of first and second dose of tablet was noted and time at which patient delivers was also noted to know the induction-delivery interval. If Bishop Score improved more than 5 then amniotomy followed by augmentation, if necessary was performed. If Bishop score did not improve after 2 doses, it was considered induction failure and an indication for caesarean section. Possible side effects were also noted.
Results: Induction to delivery interval was longer in IMN group as compared to PGE2. There was no case of hyperstimulation in both groups. Side effects of IMN were mild and not clinically significant .
Conclusion: Like prostaglandin E2, the nitric oxide donor Isosorbide Mononitrate can be used for cervical ripening and induction of labour

PDF