Pattern of Haemoglobin Disorders

Abstract

Background: To study the pattern of different
haemoglobin disorders in our set up.
Methods: In this descriptive study, patients referred for
haemoglobin electrophoresis were included. Detailed
clinical history was taken. Physical findings were noted.
Peripheral blood film and haemoglobin electrophoresis
was performed .
Results: Out of total 666 referred cases , 176 (26.4%)
were detected to have abnormal haemoglobin. The
commonest disorder was beta thalassaemia trait (13.2%).
Beta thalassaemia major was found in 9.9 % cases. Other
haemoglobin disorders like HbD,HbE, and HbS alone or
in combination with beta thalassaemia were detected in
2.95% cases. One case of beta thalassaemia minor revealed
normal pattern on haemoglobin electrophoresis and was
diagnosed on molecular studies
Conclusion: The increased trend of haemoglobin
electrophoresis employment predicts a decline in
homozygous states of autosomal recessive haemoglobin
disorders