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Abstract
Background: Angiotensin converting enzyme inhibitors and angiotensin receptor blockers are being extensively used these days for treatment of mild to moderate hypertension. The selection of either of the two drugs is usually based on physician preference. The purpose of the study was to compare antihypertensive effect of fixed dose Enalapril and Losartan in Essential Hypertension. Methods: In this interventional study therapeutic option of Enalapril (Group 1) ) and Losartan (Group 2) were offered to 100 newly diagnosed cases of hypertension . The patients were followed on subsequent visits (6 in total) and the systolic and diastolic blood pressures were recorded carefully. Results: Total number of patients becoming normotensive with Enalapril was 38 (out of 50) and with Losartan were 28 (out of 50). Conclusion: Enalapril had significantly better antihypertensive effect than Losartan in essential hypertension at the end of six months therapy.