Prognostic Stratification of Prostatic Cancer According to Modified Gleason Grading System

  • Mir Attaullah Department of Pathology, Gajju Khan Medical College Swabi
Keywords: Prognostic Stratification, Prostatic Cancer, Modified Gleason Grading System


Background : To assess the prognostic stratification of prostatic cancer according to modified Gleason Grading System
Methods: In this observational study 65 patients having prostatic carcinoma, who underwent prostatectomy by different surgical procedures were included. Lab request forms and histopathology reports of these patients were reviewed for prognostic grade groups. Gleason grade ≤6; 3 + 4; 4 + 3; 8 and 9–10 were assigned by two histopathologists separately to each prostatic cancer in addition to already assigned Gleason grades.
Results: Sixty five patients were found to be diagnosed with prostatic carcinoma. Age ranged from 64-85 years. Eight patients were found incidentally to have prostatic cancer in T1 stage with six having grade group I cancer, one with grade group II and the one with a grade group III cancer. The remaining 57 cases were already diagnosed before surgery by different diagnostic tests. Out of these 57 cases 15 had Gleason grade 7 cancer (7 with grade group II and 8 with grade group III), 18 had Gleason grade 8 (All with grade group IV) and 24 cases had combined Gleason grade 9 and 10 cancer (All with grade group V). Cancer of all of these 57 cases was beyond T1 stage. Thirty cases were in stage T2, 20 in stage T3 and only 7 in stageT4.
Conclusion: While retaining the essence of the conventional Gleason system, the 2014 modified system of grade groups categorize patients of prostatic carcinoma, prognostically with more accuracy acceptable to both clinicians and patients.

How to Cite
Attaullah M. Prognostic Stratification of Prostatic Cancer According to Modified Gleason Grading System. JRMC [Internet]. 30Dec.2016 [cited 20Jun.2021];20(4):281-4. Available from: