Official publication of Rawalpindi Medical University
Doppler Waveform Abnormalities of Hepatic Veins with Histological Changes in Chronic Hepatitis - C Infection
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Areej Amber Khan , Hina Nasir, M Habib Afzaal, Samia Amin. Doppler Waveform Abnormalities of Hepatic Veins with Histological Changes in Chronic Hepatitis - C Infection. JRMC [Internet]. 2016 Sep. 30 [cited 2024 Mar. 28];20(3). Available from: https://journalrmc.com/index.php/JRMC/article/view/168

Abstract

Background :.To study the diagnostic accuracy of
the abnormalities in Doppler waveform of hepatic
veins by comparing with histological changes in
chronic liver disease (HCV infection).
Methods: In this cross sectional study 150 patients
with chronic hepatitis C infection were included.
Patients were subjected to real time Ultrasound and
Doppler scanner, Using a 3.75 MHZ sector
transducer through a trans-abdominal approach .
The sample volume, as large as at least one third of
the vessel’s diameter, was positioned within the
middle hepatic vein at a distance of 3-6 cm from the
outlet into the inferior vena cava. Histopathology
results were taken as gold standard. The New
Inuyama scoring system was used to assess the
fibrosis stage. The sensitivity, specificity, positive
predictive value (PPV) and negative predictive
values (NPV) were calculated for Doppler US. Data
was analyzed by SPSS version 14.
Results: In our study the diagnostic accuracy of the
abnormalities in Doppler waveform of hepatic veins
by comparing with histological changes (gold
standard) in chronic liver disease (HCV infection)
was calculated in 79%, sensitivity 86%, specificity
61%, PPV 83% and NPV 67%
Conclusion:The study concludes that Doppler
ultrasound is equally a very reliable and dependable
technique for the validation of Doppler
ultrasonography of hepatic veins in diagnosis of
chronic liver disease due to HCV infection as
histopathological grading.

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