Effectiveness of Vitamin D in Prevention of Dengue Haemorrhagic Fever and Dengue Shock Syndrome

Abstract

Background: To compare the risk and severity of development of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome(DSS) in patients receiving Vitamin D supplement compared to those not receiving it.
Methods: Diagnosed patients of DF (n=124) were enrolled in this comparative study. Patients were randomized into two groups having 62 participants in each group. Group A received single dose of 200,000 IU Vitamin D and Group B received no intervention. Both groups were followed for development of DHF or DSS. Chi square was applied to compare the groups.
Results: One patient (1.6%) in Group A developed DHF. Seventeen (27%) patients in Group B progressed to DHF. The relationship between Vitamin D and progression to DHF was significant, X2 (2, N=170) =16.43, p= 0.000). The calculated relative risk was 0.0588 (95% confidence interval, .0081 to .4285; p for trend = 0.0588).
Conclusion: Vitamin D decreases the risk of DHF and may have a role in management of dengue fever.