Official publication of Rawalpindi Medical University
Effectiveness of Vitamin D in Prevention of Dengue Haemorrhagic Fever and Dengue Shock Syndrome
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How to Cite

1.
Sadaf Zaman , Muhammad Rizwan Mahmud ,Mohammad Ali Khalid ,Aqsa Zahid,Sadaf Khalid,Irum Kabir, Shehzad Manzoor, Haider Zaigham Baqai SZ , MRM ,Mohammad AK ,Aqsa ZKKSMHZB. Effectiveness of Vitamin D in Prevention of Dengue Haemorrhagic Fever and Dengue Shock Syndrome. JRMC [Internet]. 2017 Sep. 30 [cited 2024 Jun. 25];21(3). Available from: https://journalrmc.com/index.php/JRMC/article/view/17

Abstract

Background: To compare the risk and severity of development of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome(DSS) in patients receiving Vitamin D supplement compared to those not receiving it.
Methods: Diagnosed patients of DF (n=124) were enrolled in this comparative study. Patients were randomized into two groups having 62 participants in each group. Group A received single dose of 200,000 IU Vitamin D and Group B received no intervention. Both groups were followed for development of DHF or DSS. Chi square was applied to compare the groups.
Results: One patient (1.6%) in Group A developed DHF. Seventeen (27%) patients in Group B progressed to DHF. The relationship between Vitamin D and progression to DHF was significant, X2 (2, N=170) =16.43, p= 0.000). The calculated relative risk was 0.0588 (95% confidence interval, .0081 to .4285; p for trend = 0.0588).
Conclusion: Vitamin D decreases the risk of DHF and may have a role in management of dengue fever.

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