Nitrofurantoin and Fosfomycin, effective oral empirical treatment options against multidrug resistant Escherichia coli

  • Saima Naseem Dow University Of Health Sciences
  • Ambreen Fatima
  • Sahar Iqbal
  • Fatima Fasih
  • Syed Talha Naeem
  • Uzma Bukhari
Keywords: Antibiotic resistance, antibiotic susceptibility, Escherichia coli, Urinary tract infection, Bacteria


The present study is designed to monitor antibiotic susceptibility pattern of Escherichia coli to assist in forecasting empirical therapy of urinary tract infection.
It is a retrospective cross sectional study. It was carried out at Dow Diagnostic Research and Reference Laboratory for a period of 3 months from February 2017 to April 2017. A data of total 5000 urine culture and sensitivity test reports was taken from the medical record. The data was analyzed by SPSS version 16.
Out of 5000 urine samples processed, 1565 showed significant bacterial growth. Escherichia coli was the most common pathogen isolated. Meropenem, Amikacin, Fosfomycin and Nitrofurantoin respectively were found to be the most sensitive antibiotics against Escherichia coli.
Fosfomycin and Nitrofurantoin are effective oral antibiotics against Escherichia coli causing urinary tract infection. The present study may help clinicians in making rational choice of empirical treatment of the patients.


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How to Cite
Naseem S, Fatima A, Iqbal S, Fasih F, Naeem S, Bukhari U. Nitrofurantoin and Fosfomycin, effective oral empirical treatment options against multidrug resistant Escherichia coli. JRMC [Internet]. 31Dec.2021 [cited 21Jan.2022];25(4). Available from: