Official publication of Rawalpindi Medical University
Effect of Platelet Additive Solution (PAS) on Random Donor Platelet Concentrates
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1.
Saira Bashir , Iram Aftab, Sadia Akbar , Shabbir Hussian , Nusrat Bano , Shahida Mohsin. Effect of Platelet Additive Solution (PAS) on Random Donor Platelet Concentrates. JRMC [Internet]. 2016 Sep. 30 [cited 2024 Mar. 29];20(3). Available from: https://journalrmc.com/index.php/JRMC/article/view/180

Abstract

Background: To observe in vitro parameters of
stored platelets in PAS as compared to plasma for 10
days.
Methods: A comparative study was carried out on
42 samples of random donor platelet concentrates
(PC). They were divided into two groups of 21
samples each and stored in incubator at 22°C. In one
group plasma was replaced with PAS. Sampling was
done on day 0, 3, 5, 7, 8, 9 and 10. Bacterial cultures
were carried out. All the samples,which showed
contamination, were excluded from the study.
Results: pH and glucose levels were reduced in
both groups but they dropped more rapidly in PC
stored in plasma than in PAS (p-value ≤ 0.001).
However, the difference in LDH levels between two
groups was not statistically significant. The mean
values of PO2 were reduced whereas mean values of
PCO2 were increased in both groups, but these
changes were seen much less in PC stored in PAS (pvalue
≤ 0.001). The results showed that difference in
all parameters between two groups was highly
significant (p-value ≤ 0.001) except LDH.
Conclusion: All the in vitro parameters were well
preserved in PC stored in PAS than in plasma.

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