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Frequency of pregnancy induced hypertension and its association with elevated serum beta human chorionic gonadotropin levels during mid trimester of pregnancy

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Habib S, Haq AI ul, Bashir S, Sadiq N, Majeed N, Waheed N. Frequency of pregnancy induced hypertension and its association with elevated serum beta human chorionic gonadotropin levels during mid trimester of pregnancy. JRMC [Internet]. 2023 Jun. 24 [cited 2024 Jun. 25];27(2). Available from:


Objective: To determine the frequency of PIH amongst elevated beta-hCG levels and non-elevated beta-hCG in the mid-trimester of pregnancy.

Materials and Methods: It was Descriptive case series conducted for six months (02-12-2019 to 02-06-2020) in OPD of Gynae Unit-II, Holy Family Hospital, Rawalpindi. A total of one hundred and twenty-two (n=122) normotensive pregnant females at 13-20 weeks gestational age and 18-35 years of maternal age were selected in this study after informed consent from every patient. The frequency of PIH in patients with elevated serum beta-hCG was measured. Data were analyzed using SPSS version 20. Effect modifiers were controlled by stratification. A p-value of ≤ 0.05 was considered significant.

Results: Mean beta-hCG levels in the total study population were found to be 7305.09±3900.64 IU/mL. Median b-hCG levels in our study population were noted as 6936.15 IU/mL. Pregnancy-induced hypertension was found positive in 16 (13.1%) patients. Raised beta-hCG levels were present in 10 (8.2%) patients. The frequency of PIH in raised beta-HCG levels was found in 7/10 (70%) of patients. We found a statistically significant (p-value ≤ 0.05) difference in the frequency of PIH among patients with elevated and not-elevated beta-hCG levels.

Conclusion: It is evident from my study that patients with raised levels of serum β-hCG during mid-trimester pregnancy are at increased risk to develop hypertensive disorders of pregnancy. We further elaborated that there is a statistically significant difference in various effect modifiers such as maternal age, gestational age, residential status, and BMI  for developing  PIH among patients with elevated and non-elevated beta-hCG levels.


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