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Effects Of Phototherapy On Serum Calcium Level In Neonates With Hyperbilirubinemia

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Javaid Q- tul-A, Aziz S, Noor-ul-Ain, Abid U, Afzal A, Javaid U. Effects Of Phototherapy On Serum Calcium Level In Neonates With Hyperbilirubinemia . JRMC [Internet]. 2023 Jun. 24 [cited 2024 Jun. 25];27(2). Available from:


Objective: To study the frequency of hypocalcemia in neonates receiving phototherapy with indirect hyperbilirubinemia Materials and Methods: Descriptive case series study was conducted from September 5, 2018, to March 5, 2019, in the NICU of the Paediatric Department Benazir Bhutto Hospital, Rawalpindi.

Approval was sought from the hospital’s ethical committee. Neonates fulfilling inclusion criteria were enrolled in the study after obtaining informed consent from the parents. Before giving phototherapy, serum calcium levels were checked. Phototherapy was given for 48 hours. Serum calcium levels were reassessed after 48 hours of phototherapy. Data was entered on a structured proforma and statistical analysis of data was performed.

Results: Out of 150 patients enrolled in the study 83(55.33%) were male and 67(44.67%) were female. The mean age of patients was 52.52 hours with minimum and maximum ages of 26 hours and 80 hours. The mean Indirect serum bilirubin level was 15.59 ± 2.36. A total of 50(33.33%) cases had hypocalcemia after 48 hours of phototherapy, all of these neonates had normal calcium levels before phototherapy. When hypocalcaemia was stratified for gestational age, birth weight and serum bilirubin levels at baseline, there was no significant difference in the frequency of hypocalcaemia concerning these effect modifiers.

Conclusion: It is concluded that the frequency of hypocalcemia is higher in neonates with indirect hyperbilirubinemia after receiving phototherapy. One needs to be vigilant in dealing with neonates in this context, while serial measurements of calcium levels and monitoring for complications of hypocalcaemia should be included in every institution’s policy


Kliegman R, Stanton B, St. Geme J, Schor N, Behrman R. Nelson textbook of pediatrics. 20th ed. Phialdelphia, PA: Elsevier; 2016. p. 871.

M Bayomy A, Mahmoud Solaiman A. Serum Calcium Level in Neonates under Phototherapy with and without Head Covering. AJMMS. 2017;7(2):55-60.

Melton K,Akinbi HT.Neonatal jaundice:strategies to reduce-billirubin-induced complications.Postgraduate medicine.1999;106(6):167-78.

Khan M, Malik KA, Bai R. Hypocalcemia in jaundiced neonates receiving phototherapy. Pak J Med Sci. 2016;32(6):1449-52.

Durga T, Kumar R. The Effect of Phototherapy on Serum Ionized Calcium Levels in Neonates with Unconjugated Hyper Bilirubinemia. J Evid Based Med Healthc. 2015;2(17):2596-601.

Prabhakar N, Lazarus M, Ahirwar M. Effect of phototherapy on serum ionic calcium level in neonates with hyperbilirubinemia. Eur J Pharm Med Res. 2016;3(4):510-4.

Asl AS, Zarkeshl M, Heidarzadeh A, Maleknejad S, Hagikhani K. The effect of phototherapy on urinary calcium excretion in term neonates. Saudi J Kidney Dis Transpl. 2016;27(3):486-92.

Barekatain B, Badiea Z, Hoseini N. The effect of head covering in prevention of phototherapy-induced hypocalcemia in icterus newborns with gestational age less than 35 weeks. Adv Biomed Res. 2016;5(176):2277-9175. 91.

Eghbalian FJAJoCM. The study of early neonatal hypocalcemia in the educational hospitals of Hamadan university of medical sciences.2004;11(3):48-52.

Lundberg WG. Medscape.

Yadav RK, Sethi R, Sethi AS, Kumar L, Chaurasia OSJPsJSR. The evaluation of the effect of phototherapy on serum calcium level.People,s JSci Res. 2012;5(2):1-4

Gupta R, Singh D, Yadav M, Panda PK, Nagaraj N, Bana SKJIJoCH. Assessment of phototherapy-induced hypocalcemia and its correlation with urinary calcium excretion in term and preterm newborns with neonatal hyperbilirubinemia: A cross-sectional study with controls. Indian Journal of Child Health.2018:626-30.

Bahbah MH, ElNemr FM, ElZayat RS, Aziz EAKJMMJ. Effect of phototherapy on serum calcium level in neonatal jaundice.Menoufia Medical Journal.2015 Apr 1:28(2):426.

Gheshmi AN, Naderi S, Homayrani E, Safari BJEp. Prevalence of hypocalcemia after phototherapy among neonates who underwent phototherapy in Koodakan Hospital in Bandar Abbas in 2013. Electronic physician.2015 Oct;7(6):1387.

Xiong T, Qu Y, Cambier S, Mu D. The side effects of phototherapy for neonatal jaundice: what do we know? What should we do? European journal of pediatrics. 2011;170(10):1247-55.

Borkenhagen JF, Connor EL, Stafstrom CEJPn. Neonatal hypocalcemic seizures due to excessive maternal calcium ingestion.Pediatric Neurology.2013 Jun 1;48(6):469-71.

Korkmaz HA, Özkan B, Terek D, Dizdarer C, Arslanoğlu SJJocripe. Neonatal seizure as a manifestation of unrecognized maternal hyperparathyroidism. Journal of Clinical Research in Pediatric Endocrinology2013 Sep;5(3):206

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