Official publication of Rawalpindi Medical University
Efficacy Of Tranexamic Acid in Reducing Blood Loss in Primary Total Knee Replacement

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Total knee replacement, Tranexamic acid, Efficacy.

How to Cite

Younas MI, Rauf F, Mustafa MS, Janjua SN, Iqbal S, Habib K. Efficacy Of Tranexamic Acid in Reducing Blood Loss in Primary Total Knee Replacement. JRMC [Internet]. 2023 Jun. 24 [cited 2024 Jun. 25];27(2). Available from:


Objective: To determine the efficacy of tranexamic acid in reducing blood loss in primary total knee replacement.

Material and Methods: A total of 96 patients having a diagnosis of primary knee osteoarthritis made up the population sample. The Total Knee Replacement patients were separated into two groups. Patients in Group B used Intra venous tranexamic acid, but those in Group A did not use tranexamic acid during the course of the operation or afterwards.

Results: Mean age of the patients recorded in group A 63.79±6.60 (years) and in group B 62.96±7.89 (years). The majority of the patients in both groups were females. After surgery, Group B patients who received tranexamic acid reported less blood loss and less haemoglobin reduction as compared to the control group.

Conclusion: From our study, we conclude that Tranexamic acid used intravenously during total knee arthroplasty considerably lowers postoperative blood loss.


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