Official publication of Rawalpindi Medical University
Snake Bite: Clinical Profile and Evaluation of Effective Anti-Snake Venom Dose
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How to Cite

1.
Asif Raza Bhatti, Arshad Iqbal Satti,Muhammad Ali Khalid. Snake Bite: Clinical Profile and Evaluation of Effective Anti-Snake Venom Dose. JRMC [Internet]. 2010 Jun. 30 [cited 2024 Mar. 29];14(1). Available from: https://journalrmc.com/index.php/JRMC/article/view/709

Abstract

Background: To determine the optimal dose of antisnake venom required to treat hemotoxic snake bite more effectively. Methods: In this interventional study, out of 52 patients 46 patients with the features of systemic envenomation .i.e. deranged coagulation profile, nephrotoxic or neurotoxic features were assessed clinically and through laboratory tests, while 06 patients had no feature of envenomation. Patients with systemic envenomation were given Antisnake venom. Results: Hemotoxicity was the most common clinical manifestation of snake bite i.e. 39 patients of hemotoxic envenomation, 4 with neurotoxic features while 03 patients had mixed toxicity i.e. hemotoxic, neurotoxic and nephrotoxic. 12 patients responded to single dose of 06 vials (10 ml each vial; total dose of 60 ml), 28 patients required further dose of anti snake venom after initial dose of 6 vials while 06 patients received even higher dose of anti snake venom i.e. 18 vial (180 ml) with blood transfusion. Of these 06 patients, 02 required mechanical ventilation, 02 with nephrotoxicity were referred to dialysis unit, and 02 mortalities were encountered, one with intracranial bleed and other with mixed toxicity and delayed presentation of patient. Conclusion: Most patients with envenomation require higher dose of anti snake venom . An increase in morbidity and mortality is mainly due to delayed presentation after snake bite and under dosage of ASV.

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