Comparison of Efficacy of Febuxostat with Allopurinol in Lowering Serum Urate Levels

  • Muhammad Osama Osama Department of Nephrology, Holy Family Hospital and Rawalpindi Medical University;
Keywords: Febuxostat,, Allopurinol, Hyperuricemia


To compare the efficacy of Febuxostat with Allopurinol in lowering serum urate levels
Methods: In this randomized controlled trial a total of 60 patients with hyperuricemia above 18 years of age were included. Thirty patients were given Allopurinol and 30 patients were given Febuxostat for 4 weeks. Hyperuricemia was defined as serum uric acid level of greater than 6mmol/L. Uric acid was measured at 2 and 4 weeks from start of treatment. Chi-square test was applied to compare the efficacy of drugs among the two groups.
Results: After 4 weeks of therapy uric acid reduced to <6mg/dl successfully in 42/60 patients (70 %) . In Febuxostat group 26/30 (86.7%) patients responded to treatment with uric acid levels <6mg/dl while in Allopurinol group 16/30 (53.3%) patients showed uric acid <6mg/dl with a significant p= 0.005 . Febuxostat was effective in 22/25 (88%) of male (mean age 57.50 ± 8.695years) and 4/5(80%) of female(mean age 57.75 ± 8.578 years)patients while Allopurinol was effective in 12/23 (52.2%) of males (mean age 56.33 ± 11.758 years ) and 4/7 (57.1%) of females (mean age 54.25 ± 8.770 years ) .
Conclusion: The efficacy of treatment was significantly higher in Febuxostat group as compared to the Allopurinol group

How to Cite
Osama MO. Comparison of Efficacy of Febuxostat with Allopurinol in Lowering Serum Urate Levels. JRMC [Internet]. 30Jun.2017 [cited 9May2021];21(2):113-7. Available from: