Low Dose Perioperative Lidocaine Infusion for Post-Operative Pain in Open Cholecystectomy
compare low dose peri-operative lidocaine infusion and placebo for post-operative mean pain score and mean analgesic requirement in open cholecystectomy.
Methods: In this prospective randomized comparative study 120 patients, undergoing open cholecystectomy in general anaesthesia, were included. Patients were randomly allocated to either lidocaine infusion (L) or saline group (S) using systematic randomized sampling with 60 patients in each group. Patients in the lidocaine infusion group were given bolus injection of lidocaine 30 minutes before the skin incision followed by a continuous intraveonous via infusion pump whereas the patients in the saline group received 0.9% normal saline in equal volume and in the same manner. The infusion was continued throughout the surgery and was terminated 60 min after the skin closure.
Results: Out of the 120 patients 34 (28.3%) were male while 86 (71.7%) were female. Mean age was 41.32±11.512 years. Both mean VAS pain score and mean analgesic requirement were found to be significantly lower in the lidocaine Group (p-values 0.04 and 0.29 respectively), as compared to controls.
Conclusion: Peri-operative low dose systemic lidocaine appears to reduce pain in the immediate post-operative period.
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