Diagnostic Accuracy of Serum Hepatitis B Virus DNA Levels and ALT for Liver Fibrosis

  • Madeeha Nazar Medical Unit I, Holy Family Hospital and Rawalpindi Medical College
Keywords: Chronic liver disease., HBV, ALT, Liver fibrosis,Biopsy

Abstract

Background: To determine the diagnostic accuracy of combined serum HBV DNA and serum ALT levels for significant liver fibrosis in chronic Hepatitis B patients.
Methods: In this cross sectional study confirmed cases of Hepatitis B were enrolled. Inclusion criteria was age more than 20 and both genders, while those cases who had history of Hep C or were on treatment of Hep B were excluded. Patients’samples were taken for HBV DNA and ALT to predict the presence of liver fibrosis.
Results: Out of total 130 cases, there were 72 (54.5%) males with a mean age of 43.78± 10.28 years. The results of HBV DNA + ALT showed 51 (38.6%) patients to have fibrosis, whereas endoscopic diagnosis of esophageal varices was confirmed in 40 (30.3%) patients.Sensitivity of HBV DNA + ALT for diagnosis of fibrosis was found to be 55%, specificity 66.6%and diagnostic accuracy 65%.
Conclusion: Combined HBV DNA & ALT values can be advised as predictor of liver fibrosis.

Published
2018-01-27
How to Cite
1.
Nazar M. Diagnostic Accuracy of Serum Hepatitis B Virus DNA Levels and ALT for Liver Fibrosis. JRMC [Internet]. 27Jan.2018 [cited 20Jun.2021];20(4):251-3. Available from: https://journalrmc.com/index.php/JRMC/article/view/129
Section
Articles