Official publication of Rawalpindi Medical University
Assessment Of Predictive Value Of Serum Uric Acid Levels For Low Birth Weight In Pre-Eclampsia

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Asma S, Muntaha ST, Liaqat A, Hassan F, Hayat S, Ahmed R. Assessment Of Predictive Value Of Serum Uric Acid Levels For Low Birth Weight In Pre-Eclampsia. JRMC [Internet]. 2023 Sep. 26 [cited 2024 May 8];27(3). Available from: https://journalrmc.com/index.php/JRMC/article/view/2262

Abstract

OBJECTIVE: To assess the diagnostic accuracy of raised serum uric acid level in females with pre-eclampsia, in predicting low birth weight.

SUBJESTS & METHODS: Cross sectional study carried out at Gynecology Department, FGSH Poly Clinic, Islamabad & duration of study was 6 months from July 21, 2021 to Jan 20, 2022. A total of 225 Preeclampsia pregnant female were clinically examined and included in the study. Blood sample were collected for serum uric acid and followed till the birth of the baby.

RESULTS: The  study  included  age  ranged  from  18  up  to  40  years.  Average age was 28.69years +5.01SD. Sensitivity & specificity of uric acid level in Serum in diagnosis of low birth weight are 85.71%  and  81.42%  respectively while  it  has  positive  predictive & negative predictive value  of  51.43% &  96.13% respectively.  Diagnostic accuracy of uric acid level in serum was 82.22%.

CONCLUSION: Uric acid level in serum is of great diagnostic and prognostic importance in women with pre-eclampsia & helps in predicting low birth weight.

https://doi.org/10.37939/jrmc.v27i3.2262

References

Zangana JM, Hamadamen AI. Serum uric acid as a predictor of perinatal outcome in women with pre-eclampsia. Int J Med Res & Health Sci. 2018;7(3):168-74.

Nisa SU, Shaikh AA, Kumar R. Maternal and fetal outcomes of pregnancy-related hypertensive disorders in a tertiary care hospital in Sukkur, Pakistan. Cureus 2019;11(8):2-8. doi:10.7759/cureus.5507

B Shanthirani, A Parimalam. The Study of Serum Uric Acid as a Biochemical Indicator for Maternal and Fetal Outcome in Gestational Hypertension. International Journal of Scientific Study. 2020; 8 (9):53-7.

Rothenbacher D, Braig S, Logan CA, Feike G, Müller M, Koenig W, et al. Association of maternal uric acid and cystatin C serum concentrations with maternal and neonatal cardiovascular risk markers and neonatal body composition. Plos one 2018;13(7). doi.org/10.1371/journal.pone.0200470

Lin J, Hong XY, Tu RZ. The value of serum uric acid in predicting adverse pregnancy outcomes of women with hypertensive disorders of pregnancy. Ginekologia polska 2018;89(7):375-80.doi: 10.5603/GP. a2018.0064

Ryu A, Cho NJ, Kim YS, Lee EY. Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia. Medicine(Baltimore). 2019;98(18). doi: 10.1097/MD.0000000000015462.

Le TM, Nguyen LH, Phan NL, Le DD, Nguyen HVQ, Truong VQ, et al. Maternal serum uric acid concentration and pregnancy outcomes in women with pre- eclampsia/eclampsia. Int J Gynecol Obstet. 2019;144(1):21-6. doi: 10.1002/ijgo.12697

Livingston JR, Payne B, Brown M, Roberts JM, Côté AM, Magee LA, et al. Uric Acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia. J Obstet Gynaecology Canada. 2014;36(10):870-7. doi: 10.1016/S1701-2163(15)30435-7.

T L-A Hawkins , J M Roberts, G J Mangos, G K Davis, L M Roberts, M A Brown.Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study.BJOG 2012;119(4):484-92.doi: 10.1111/j.1471-0528.2011. 03232.

Lüscher BP, Schoeberlein A, Surbek DV, Baumann MU. Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice. Cells.2022;11(22):3703.doi:10.3390/cells11223703.

Sakr HI, Khowailed AA , Al-Fakharany RS , Abdel-Fattah DS , Taha AA .Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study. Rev Recent Clin Trials.2020;15(3):227-39.doi:10.2174/1574887115666200709142119

Mazzali M, Kanellis J, Han L, Feng L, Xia Y, Chen Q. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure‐independent mechanism. Am. J. Physiol. Renal. Physiol.2002;282(6):991-97.doi10.1152/ajprenal.00283.2001

Bellos I, Pergialiotis V, Loutradis D, Daskalakis G. The prognostic role of serum uric acid levels in preeclampsia: A meta-analysis. Clin Hypertens. 2020; 22(5):826–34.doi:10.1111/jch.13865.

Yassaee F. Hyperuricemia and perinatal outcomes in patients with severe preeclampsia. Iranian J Med Sci. 2015;28(4):198-99.

Redman CW, Beilin LJ, Bonnar J, Wilkinson RH. Plasma-urate measurements in predicting fetal death in hypertensive pregnancy. Lancet. 1976;26(1):1370–73.doi:10.1016/s0140-6736(76)93024-5.

D’Anna R, Baviera G, Scilipoti A, Leonardi I, Leo R. The clinical utility of serum uric acid measurements in pre-eclampsia and transient hypertension in pregnancy. Panminerva Med. 2000; 42(2):101–03. doi:10.1002/pd.2339.

Hawkins TL, Roberts JM, Mangos GJ, Davis GK. Uric acid remains a marker of poor outcome in hypertensive pregnancy. BJOG. 2012; 119(4):484-92. doi: 10.1111/j.1471-0528.2011.03232.

Lim KH, Frideman SA, Ecker JL, Kao L. The clinical utility of serum uric acid measurments in hypertensive diseases of pregnancy. Am J Obstet Gynecol. 1998; 178(5):1067-71. doi: 10.1016/s0002-9378(98)70549-6.

Hosna AU, Bhuiyan M, Ferdous NE, Ahmed K. Effects of hyperuricemia on perinatal outcome in hypertensive disorder of pregnancy. Uni Heart J. 2008;4:36- 40.doi:10.3329/UHJ.V4I2.2074

Akahori Y, Masuyama H, Hiramatsu Y. The correlation of maternal uric acidconcentration with small-for-gestational-age fetuses in normotensive pregnant women. Gynecol Obstet Invest. 2012; 73(2):162-7.doi: 10.1159/000332391

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Copyright (c) 2023 Sadaf, Sidra Tul Muntaha, Amerzish, Farhan, Sara, Rafiq