Official publication of Rawalpindi Medical University
IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features

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Keywords

Ig4 disease
histopathology

How to Cite

1.
Taimur F, Manzoor A, Saad M, Tahir F, Khan S, Khalid A. IgG4-Related Orbital Disease: An Analysis of Patient Profiles, Clinical Presentation, And Histopathological Features. JRMC [Internet]. 2024 Jun. 29 [cited 2024 Jul. 17];28(2). Available from: https://journalrmc.com/index.php/JRMC/article/view/2501

Abstract

Objective: To study various presentations of patients with a histopathologically confirmed diagnosis of IgG4 disease.

Methods: This study is a retrospective review of medical records from the IgG4-RD registry at the Al-Shifa Trust Eye Hospital. Nine patients with orbital manifestations were identified. All had histopathologically confirmed diagnoses of IgG4-RD. Data obtained from the medical records included patient demographic information (name, age, gender), brief patient history, clinical presentation, histopathology reports, and diagnoses.

Results: Most patients presented with proptosis and swelling in various parts of the orbital area. Some patients also presented with pain and diplopia. The most common orbital structures involved were the lacrimal gland and the extraocular muscles, with some patients also having soft tissue involvement. 4(44%) patients had bilateral orbital involvement, while the remaining 5(55%) had unilateral disease.

Conclusion: Ophthalmic involvement is a feature of IgG4-RD and has significant implications regarding the diagnosis, prognosis, and treatment of patients with IgG4 disease.

https://doi.org/10.37939/jrmc.v28i2.2501
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Copyright (c) 2024 Fariha Taimur, Amna Manzoor, Muhammad Saad, Faizan Tahir, Sumeya Khan, Aashar Khalid