Implications Of Ingesting Soft Drink And Energy Drink On Hepatic Microcirculation Of Albino Rat

Abstract

Objective: To compare the diameter of the centrilobular vein as well as its congestion along with that of sinusoids and portal vein of the rat liver after ingestion of caffeinated soft drinks and energy drinks which were given caffeinated soft drinks and energy drinks.

Method: 11ml/kg body weight each, of distilled water to the control group, caffeinated soft drink to the SD group and caffeinated energy drink to the ED group was given respectively for 8 weeks. Later, the rats were sacrificed, the liver dissected out, slides prepared and stained with H & E for microscopic observation.

Result: Morphometric analysis showed an increase in the diameters of centrilobular veins of both experimental groups receiving caffeinated SD and ED compared to control group p-values <0.001. The SD group was affected more (p-value 0.024)

Conclusion: Caffeine-containing ED and SD are held responsible for congestion and dilatation of centrilobular veins, portal veins and sinusoids of albino rats, the augmented effect seen with SD could be because the high taurine content of ED would have interfered with the metabolism of the caffeine.