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Abstract
Background: To determine the effects of previous overt hyperthyroidism due to Graves’ disease on BMD in euthyroid pre and post menopausal females.
Methods: In this cross-sectional, non-interventional study,fifty patients with previous hyperthyroidism due to Graves’ disease (premenopausal:25, postmenopausal: 25) who remained euthyroid for at least 6 months prior to study were included and compared with fifty- matched respective controls. Free thyroxine (FT4), TSH, and BMD were measured. Comparison was made between two groups and also between patients and controls in each group.
Results: Statistically significant (p <.0.05) lower whole body BMD expressed as Z-score was observed in post-menopausal women having history of hyperthyroidism due to Graves’ disease than matched controls. Bone mineral density, expressed as Z-score in whole body and lumbar spine was significantly lower in group II (post-menopause) in comparison to group I (pre-menopause) patients. Time of euthyroidism and time of evolution of disease has significant effect on BMD in post-menopausal women.
Conclusion: Graves’ hyperthyroidism affects BMD only in post menopausal females even after achievement of euthyroid status.