Keywords
Iron
Anemia
oral ferrous sulphate
How to Cite
Abstract
OBJECTIVE
The goal of this study is to assess the effectiveness of parenteral iron sucrose therapy vs oral iron supplements in the treatment of iron deficiency anaemia (IDA) in the postpartum period.
METHODOLOGY:
This study is conducted in the OBS and Gynae department of PAF Hospital Islamabad. This is a randomized control trial (RCT). A total of 130 women, 65 in each group were recruited who were diagnosed with iron deficiency anaemia (as per operational definition ), 48hrs after delivery. In group A females were prescribed intravenous iron sucrose therapy according to post-delivery hemoglobin level by using the formula (2.4 × (target Hb-actual Hb) × post-pregnancy weight (kg)) + 1000 mg every alternate day. In group B females were prescribed daily oral iron supplements along with folic acid. Follow-up of both groups was done after 4 weeks in OPD.
RESULTS:
The mean age was 29 years ± 2.688 in group A, while in group B it was 30 years with SD ±2.422. In group A (Intravenous iron sucrose therapy) mean ferritin level was 140.94 ± 3.292 and the mean hemoglobin level was 11.11 ± 0.710. In group B (Oral iron supplements) mean serum ferritin level was 125.34 ± 6.551 and the mean Hemoglobin level was 10.65 ± 0.623 after treatment.
CONCLUSION
Our study concludes that there is no significant difference in treatment between intravenous iron sucrose therapy and oral iron supplements for iron deficiency anaemia in the post-partum period.
References
Sultan P, Bampoe S, Shah R, Guo N, Estes J, Stave C, et al. Oral vs intravenous iron therapy for postpartum anaemia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2019;221(1):19-
e3. DOI: 10.1016/j.ajog.2018.12.016
Radhika A, Sharma AK, Perumal V, Sinha A, Sriganesh V, Kulshreshtha V, et al. Parenteral versus oral iron for treatment of iron deficiency anaemia during pregnancy and post-partum: a systematic review. J Obstet Gynecol India. 2019;69(1):13-24. DOI: 10.1007/s13224-018-1191-8
Froessler B, Cocchiaro C, Saadat-Gilani K, Hodyl N, Dekker G. Intravenous iron sucrose versus oral iron ferrous sulfate for antenatal and postpartum iron deficiency anaemia: a randomized trial. J Mat Fetal Neonat Med. 2013;26(7):654-9. DOI: 10.3109/14767058.2012.746299
Radhika AG, Sharma AK, Perumal V, Sinha A, Sriganesh V, Kulshreshtha V, et al. Parenteral Versus Oral Iron for Treatment of Iron Deficiency Anaemia During Pregnancy and post-partum: A Systematic Review. J Obstet Gynecol India. 2019;69(1):13-24.
Neogi SB, Devasenapathy N, Singh R, Bhushan H, Shah D, Divakar H, et al. Safety and effectiveness of intravenous iron sucrose versus standard oral iron therapy in pregnant women with moderate-to-severe anaemia in India: a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Glob Health. 2019;7(12):e1706-e16. DOI: 10.1016/S2214-109X(19)30427-9
Tigga MP, Debbarma AP. A comparative study to evaluate oral iron and intravenous iron sucrose for treatment of anemia in pregnancy in a poor socioeconomic region of Northeast India. Tzu- Chi Med J. 2019;32(3):258-61. DOI: 10.4103/tcmj.tcmj_99_19
Sultan P, Bampoe S, Shah R, Guo N, Estes J, Stave C, Goodnough L, Halpern S, Butwick AJ. Oral versus intravenous iron therapy for postpartum anemia: A systematic review and meta-analysis. Am J Obstet Gynecol. 2019 Jul;221(1):19–29.e3. doi: 10.1016/j.ajog.2018.12.016.
Caljé E, Groom KM, Dixon L, Marriott J, Foon R, Oyston C, Bloomfield FH, Jordan V. Intravenous iron versus blood transfusion for postpartum anemia: a systematic review and meta-analysis. Syst Rev. 2024;13:9. DOI: 10.1186/s13643-023-02400-4
Bashir K, Sabha M, Wani S, Khursheed R. Efficacy and safety of ferric carboxymaltose and iron sucrose in management of postpartum iron deficiency anemia: A comparative observational study. Int J Life Sci Biotechnol Pharma Res. 2023;12(3):1252. doi: 10.1007/s13224-017-0971-x
Das SN, Devi A, Mohanta BB, Choudhury A, Swain A, Thatoi PK. Oral versus intravenous iron therapy in iron deficiency anemia: An observational study. J Family Med Prim Care. 2020 Jul;9(7):3619–3622. DOI: 10.4103/jfmpc.jfmpc_559_20
Bhavi SB, Jaju PB. Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial. BMC Pregnan Childbirth. 2017;17(1):137. DOI: 10.1186/s12884-017-1313-9
Vishwakarma S, Rawat R, Dwivedi P, Kanti V. Comparative study of oral iron (ferrous sulphate) versus intravenous (iron sucrose) therapy in treating iron deficiency anaemia in puerperium. IJRCOG. 2018;7(9):6 doi https://doi.org/10.18203/2320-1770.ijrcog20183771.
Subhadra S, Saroj S, Kumar SP. A study to compare the efficacy and safety of intravenous iron sucrose and intramuscular iron sorbitol therapy for anemia during pregnancy. J ObstetGynecol India. 2013;63(1):18–21. Doi DOI: 10.1007/s13224-012-0248-3
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