Supplementary Files
How to Cite
Abstract
Behçet's disease is a multisystem vasculitis of unknown etiology that is chronic and recurrent. One of the most severe and vision-threatening implications is ocular inflammation. We present a case of severe ocular Behçet's disease with occlusive retinal vasculitis in a young male. A 20-year-old boy had gradually deteriorating vision in both eyes for three months before experiencing a sudden loss of vision in the left eye for two weeks. Ocular examination showed bilateral anterior uveitis with vitritis and perivasculitis. Branch retinal vein occlusion (BRVO) with macular edema and macular pseudohole was seen in the left eye, which was confirmed by fundus fluorescein angiography and optical coherence tomography. A positive pathergy test, as well as repeated oral and vaginal ulcers, confirmed the diagnosis of Behçet's syndrome with panuveitis and occlusive vasculitis. Adalimumab, azathioprine, and systemic corticosteroids were used to treat the patient; this led to a partial recovery of vision and a noticeable reduction in inflammation. Early detection of Behçet's uveitis and timely beginning of immunomodulatory therapy are essential to prevent irreversible retinal damage and subsequent visual loss.
Keywords: Behçet’s Disease, Retinal Vasculitis, Branch Retinal Vein Occlusion, Macular Edema, Adalimumab, Uveitis
References
Yazici Y, Hatemi G, Bodaghi B, Cheon JH, Suzuki N, Ambrose N, Yazici H. Behçet syndrome. Nature Reviews Disease Primers. 2021 Sep 16;7(1):67. https://doi.org/10.3390/diagnostics13010041.
Ferizi M, Gerqari A, Ferizi M. Behçet’s disease–case presentation and review literature. Open access Macedonian journal of medical sciences. 2018 Oct 3;6(10):1871. https://doi.org/10.3889/oamjms.2018.393.
Elkhoyaali A, Chaibi Z, Laaouina S, Zamani F, Mouzarii Y, Oubaaz A. Ocular manifestations revealing of Behçet’s disease: about 42 cases. Sch J Med Case Rep. 2024 Mar;3:298-302. https://doi.org/10.36347/sjmcr.2024.v12i03.016.
Ksiaa I, Abroug N, Kechida M, Zina S, Jelliti B, Khochtali S, Attia S, Khairallah M. Eye and Behçet’s disease. Journal francais d’ophtalmologie. 2019 Apr 1;42(4):e133-46. https://doi.org/10.1016/j.jfo.2019.02.002.
Mangal V, Mishra Y, Atal AT, Kochhar D, Tripathy DM, Manrai M. Fever, Uveitis, and Myocarditis as the Initial Presentation of Behcet’s Disease: A Case Report and Review of the Literature. Indian Journal of Rheumatology. 2021 Sep;16(3):338-44. https://doi.org/10.4103/injr.injr_308_20.
Gao Y, Lyu S, Bao L, Zhang M. Sudden unilateral vision loss in an adult with Behcet disease: A case report. Medicine. 2018 Dec 1;97(50):e13594. https://doi.org/10.1097/MD.0000000000013594.
Tugal-Tutkun I, Onal S, Stanford M, Akman M, Twisk JW, Boers M, Oray M, Özdal P, Kadayifcilar S, Amer R, Rathinam SR. An algorithm for the diagnosis of Behçet disease uveitis in adults. Ocular immunology and inflammation. 2021 Aug 18;29(6):1154-63. https://doi.org/10.1080/09273948.2020.1736310.
Kiafar M, Faezi ST, Kasaeian A, Baghdadi A, Kakaei S, Mousavi SA, Nejadhosseinian M, Shahram F, Ghodsi SZ, Shams H, Davatchi F. Diagnosis of Behçet’s disease: clinical characteristics, diagnostic criteria, and differential diagnoses. BMC rheumatology. 2021 Jan 15;5(1):2. https://doi.org/10.1186/s41927-020-00172-1.
Ostrovsky M, Rosenblatt A, Iriqat S, Shteiwi A, Sharon Y, Kramer M, Vishnevskia-Dai V, Sar S, Boulos Y, Tomkins-Netzer O, Lavee N. Ocular Behçet disease—Clinical manifestations, treatments and outcomes according to age at disease onset. Biomedicines. 2023 Feb 19;11(2):624. https://doi.org/10.3390/biomedicines11020624.
Zając H, Turno-Kręcicka A. Ocular manifestations of Behçet’s disease: an update on diagnostic challenges and disease management. Journal of Clinical Medicine. 2021 Nov 5;10(21):5174. https://doi.org/10.3390/jcm10215174.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyright (c) 2026 Ambreen Gull, Arsalan Sajjad, Wajeeha Rasool, Fuad Ahmad Khan Niazi