Official publication of Rawalpindi Medical University
Pleural Adenocarcinoma Presenting with Deep Venous Thrombosis: An Unusual Incidental Finding

Supplementary Files

PDF

How to Cite

1.
Umar Z, Saleem S, Maqbool F, Maryam S. Pleural Adenocarcinoma Presenting with Deep Venous Thrombosis: An Unusual Incidental Finding. JRMC [Internet]. 2026 Feb. 14 [cited 2026 Feb. 24];1(1). Available from: https://journalrmc.com/index.php/JRMC/article/view/3199

Abstract

Deep venous thrombosis (DVT) is a common vascular condition with recognized risk factors such as immobility, trauma, and hypercoagulable states. However, in patients without identifiable causes, the possibility of an underlying malignancy should be strongly considered. We report the case of a 50-year-old non-smoker male who presented with lower limb swelling secondary to extensive DVT and was incidentally diagnosed with pleural adenocarcinoma following evaluation of a right-sided pleural effusion. This case highlights the importance of maintaining a high index of suspicion for occult malignancy in patients with unprovoked DVT to enable early diagnosis and timely management.

Keywords: Adenocarcinoma, Pleural Neoplasms, Venous Thrombosis.

https://doi.org/10.37939/jrmc.v1i1.3199

References

Warrell DA, Cox TM, Firth JD. Oxford handbook of respiratory medicine. 4th ed. Oxford: Oxford University Press; 2017. p. 470–1.

Fishman JA, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI. Fishman’s pulmonology and critical care medicine. 6th ed. New York: McGraw-Hill Education; 2015. p. 1340–51, 1887–9.

Mulder FI, Horváth-Puhó E, van Es N, van Laarhoven HWM, Pedersen L, Moik F, et al. Cumulative incidence of venous thromboembolism in cancer patients in the United States. JAMA Netw Open. 2021;4(11):e2135671.

Khorana AA, Noble S, Lee AYY, Soff G, Meyer G, O’Connell C, et al. Role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism: guidance from the SSC of the ISTH. Blood. 2019;133(23):2916–22. https://doi.org/10.1111/jth.14219

Farge D, Frere C, Connors JM, Khorana AA, Kakkar A, Ay C, et al. 2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. Lancet Oncol. 2022;23(7):e334-47. https://doi.org/10.1016/S1470-2045(22)00160-7

Di Nisio M, Lee AYY, Carrier M, Liebman H, Khorana AA. Diagnosis and treatment of incidental venous thrombosis in cancer patients: guidance from the SSC of the ISTH. J Thromb Haemost. 2015;13(5):880-3. https://doi.org/10.1111/jth.12883

Chen Y, Shao J, Xu L, Xu Y. A lung cancer patient with deep vein thrombosis: a case report. BMC Cancer. 2019;19(1):1249. https://doi.org/10.1007/s11547-023-01691-w

Fortuna GMG, Fonseca AL, Vieira JS, Valente CA. Lung adenocarcinoma presenting as multiple thromboembolic events: a case report and review. Case Rep Oncol. 2020;13(3):1445-52. https://doi.org/10.1177/2324709620969482

Ba-Shammakh SA, Alanazi RM, Alqahtani BA, Alanazi NA, Althobaiti SA, Alanazi MT, et al. Bilateral deep vein thrombosis as a harbinger of lung adenocarcinoma: a rare presentation. Cureus. 2023;15(7):e42068. https://doi.org/10.7759/cureus.44229

Astoul P, Tassi GF, Boutin C, Janssen JP, Gasparini S, Loddenkemper R, et al. ERS/ATS statement on the management of malignant pleural effusions. Eur Respir J. 2018;52(1):1800349. https://doi.org/10.1093/ejcts/ezy258

Roberts ME, Neville E, Berrisford RG, Antunes G, Ali NJ; BTS Pleural Disease Guideline Group. Management of a malignant pleural effusion: British Thoracic Society pleural disease guideline 2010. Thorax. 2010;65 Suppl 2:ii32-40. https://doi.org/10.1136/thx.2010.136994

Jin Y, Gao H, Wang Y, Chen Y, Zhao J, Yang X, et al. Risk factors and impact on outcomes of lung cancer patients with deep vein thrombosis. Clin Appl Thromb Hemost. 2022;28:10732748221145074. https://doi.org/10.62347/TOVV5723

Rami-Porta R, Bolejack V, Giroux DJ, Chansky K, Crowley J, Asamura H, et al. The IASLC Lung Cancer Staging Project: the new database to inform the eighth edition of the TNM classification of lung cancer. J Thorac Oncol. 2014;9(11):1618–24. https://doi.org/10.1097/JTO.0000000000000334

Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11(1):39–51. https://doi.org/10.1016/j.jtho.2015.09.009

Detterbeck FC, Boffa DJ, Kim AW, Tanoue LT. The eighth edition lung cancer stage classification. Chest. 2017;151(1):193–203. https://doi.org/10.1016/j.chest.2016.10.010.

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Copyright (c) 2026 Zaid Umar, Samar Saleem, Faran Maqbool, Summayah Maryam