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Abstract
Background: To assess role of immunohistochemistry in identifying primary and secondary ovarian malignancies. Methods: In this descriptive cross sectional study 65 cases of ovarian malignancies diagnosed during the year 2001, with a limited immunohistochemistry support were included. An equal number of cases (65 cases) diagnosed during the year 2012, with an extended immunochemistry support, were used for the comparison. Immunostains used in these cases were CK, CK7, CK20, Cdx2, PLAP, WT1, inhibin, Calretenin, Melan A, CD99, GCDFP15, Mammoglobin LCA, CEA, AFP, CD30 and CD10. Results: The frequency of metastatic carcinoma has changed tremendously being 3% in 2001 and 35.4% in 2012. The frequencies of other malignancies in 2001 in descending order of frequency were surface epithelial tumour (74.2%), germ cell tumours (16.2%), sex cord stromal tumours (1.5%) and others (3%). In 2012, apart from metastatic carcinoma, the frequency in descending order of frequency was surface epithelial tumours (35.4%), germ cell tumours (18.5%), sex cord stromal tumours (16.2%), and others (4.6%). There was not much difference in median ages (42.74 +15.4 and 39.54 + 15.8) Conclusion: IHC has helped in identifying primary and secondary ovarian malignancies.