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Abstract
Background: To study the effects of pro-kinetic
agents on post-prandial glycaemia in type 2 diabetes
mellitus.
Methods :In this comparative study one hundred
and eighty patients with Type 2 diabetes mellitus
and features of gastroparesis were randomly
recruited. They were divided randomly into two
groups of ninety each.Group I was given oral antidiabetic
agents and placebo. Group II was given
oral anti-diabetic agents along with domperidone.
Mean levels of glycaemic difference. Difference
between Premeal and two hours postmeal and
glycaemic levels were determined and compared in
the two groups.
Results :Mean fasting blood sugar of Group I was
168.57 mg/dl and 2 hours postprandial was 296.73
mg/dl. In Group II mean fasting blood sugar was
201.24 mg/dl and mean 2 hours postprandial blood
sugar was 296.42 mg/dl. Mean difference in fasting
and 2 hours post prandial was 156.38 mg/dl and
114.15 mg/dl, respectively in Group I and II.
Conclusion: Mean difference between fasting and
2 hours postprandial blood sugar is significantly low
in patients taking prokinetic drugs, as compared to
the diabetics not taking pro-kinetic drugs.