Official publication of Rawalpindi Medical University
Clinical Manifestations and Complications of von Willebrand Disease
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How to Cite

1.
Shahida Mohsin , Maria Aslam , Shabbir Hussain , Shahla Suhail. Clinical Manifestations and Complications of von Willebrand Disease. JRMC [Internet]. 2012 Jun. 30 [cited 2024 Mar. 28];16(1). Available from: https://journalrmc.com/index.php/JRMC/article/view/599

Abstract

Background: To describe the clinical presentation and
complications of von Willebrand disease(vWD).
Methods: In this descriptive study, out of 426
patients,visiting the hemophilia welfare society Lahore, 57
cases of vWD, diagnosed on the basis of clinical features,
prolonged bleeding time (BT), prolonged APTT and
decreased vWF antigen were enrolled.
Results: Most of the patients (49.1%) were diagnosed at
less than one year of age while 35% patients were
diagnosed between 1-5 years of age and 15.8% were
diagnosed at the age of more than 5 years. Family history
of bleeding disorder was found in 60%. Common clinical
presentation of disease was epistaxis (77.2%), easy
bruising (64.9%) and mennorhagia (21.1%). Disease
complications were seen in 35% patients. Hepatitis C was
the commonest complication (31.6%). Arthropathy was
seen in 22.8%. CNS complications and Hepatitis B were
seen in 1.8% each.
Conclusion: In inherited bleeding disorders patients ,
with soft tissue bleeds, vWD is the commonest

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