Official publication of Rawalpindi Medical University
Role of Ascorbic Acid in Portal Inflammation Induced by Rifampicin
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How to Cite

1.
Iram Tassaduq , Shadab Ahmad Butt ,Muhammad Saeed. Role of Ascorbic Acid in Portal Inflammation Induced by Rifampicin. JRMC [Internet]. 2012 Jun. 30 [cited 2024 Mar. 28];16(1). Available from: https://journalrmc.com/index.php/JRMC/article/view/600

Abstract

Background: To assess the role of ascorbic acid in
portal triaditis caused by Rifampicin.
Methods: In this experimental study, thirty adult
BALB/c mice weighing 35-50 grams were taken. They were
kept under standard laboratory conditions of temperature
and humidity and light/dark cycle. Animals were given
diet pellets. Mice were randomized and divided into
three groups (n=10 animals in each group).Group A was
given rifampicin in a dose of 100 mg/kg, Group B was
given rifampicin 100 mg/kg along with Ascorbic acid 500
mg/kg orally for 6 weeks.Group C was the control group
Results: Histological examination of animals revealed
significant change in portal triaditis in experimental group
having Ascorbic Acid along with Rifampicin.
Conclusion: Ascorbic acid has a protective role against
Portal Inflammation caused by Rifampicin

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