Abstract
Background: To assess the role of ascorbic acid in
portal triaditis caused by Rifampicin.
Methods: In this experimental study, thirty adult
BALB/c mice weighing 35-50 grams were taken. They were
kept under standard laboratory conditions of temperature
and humidity and light/dark cycle. Animals were given
diet pellets. Mice were randomized and divided into
three groups (n=10 animals in each group).Group A was
given rifampicin in a dose of 100 mg/kg, Group B was
given rifampicin 100 mg/kg along with Ascorbic acid 500
mg/kg orally for 6 weeks.Group C was the control group
Results: Histological examination of animals revealed
significant change in portal triaditis in experimental group
having Ascorbic Acid along with Rifampicin.
Conclusion: Ascorbic acid has a protective role against
Portal Inflammation caused by Rifampicin