Supplementary Files
Keywords
Coenzyme Q10
L-Carnitine
Multiple Sclerosis
How to Cite
Abstract
Objective: To compare the therapeutic effects of Coenzyme Q10 & L-Carnitine on remyelination of Anterior Commissure in Cuprizone-induced rat model of Multiple Sclerosis.
Methods: Forty male Sprague Dawley rats were randomly divided into four groups. Group 1 was given a normal diet, and the remaining three groups were Multiple Sclerosis models and given 0.2% Cuprizone for 12 weeks. After 4 weeks, Group 3 received 150 mg/kg/day CoQ10, Group 4 was given 100 mg/kg/day L-Carnitine, while Cuprizone poisoning continued till 12 weeks. Rats were then dissected, and their brains were removed. Coronal sections were stained with Luxol Fast Blue stain to demonstrate the remyelination.
Results: CoQ10 was found to promote remyelination more effectively than L-Carnitine, as evidenced by significantly reduced areas of demyelination.
Conclusion: CoQ10 demonstrates greater effectiveness in promoting remyelination compared to L-Carnitine.
Keywords: Coenzyme Q10, Carnitine, Multiple Sclerosis, Remyelination
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