Official publication of Rawalpindi Medical University
A Cross-Sectional Study on Clinical Course And Outcomes of Patients Admitted To Covid-19 Intensive Care at A Tertiary Care Hospital In Islamabad

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Keywords

Covid-19
SARS-COV-2
Mortality
intensive care units
Pakistan

How to Cite

1.
Asad S, Ali M, Salman M, Saeed A. A Cross-Sectional Study on Clinical Course And Outcomes of Patients Admitted To Covid-19 Intensive Care at A Tertiary Care Hospital In Islamabad. JRMC [Internet]. 2026 Mar. 31 [cited 2026 Mar. 31];30(1). Available from: https://journalrmc.com/index.php/JRMC/article/view/2998

Abstract

Objective: To investigate different clinical and demographic parameters among COVID-19 patients admitted to the intensive care unit and to correlate these parameters with survival outcome.

Methods: This cross-sectional study was conducted at the COVID-19 Intensive Care Unit of Pakistan Air Force Hospital, Islamabad, Pakistan, from January 2021 to December 2022. Ethical review was obtained. Calculated sample size was 340. Covid-19 diagnosed patients > 18 years of age admitted to the ICU were enrolled. Data related to socio-demography, HRCT chest score, need for mechanical ventilation, duration of ICU stay, and survival outcome were collected. The data were collected, entered, and analyzed using SPSS version 22.0. A p-value of <0.05 was taken as significant.

Results: This study includes 186 males and 154 females. Mean age was 55.8 ± 14.5. 82.6 % patients were RT-PCR positive. 59.7 % had >15 HRCT chest score. 77.9% needed mechanical ventilation. 50.9% had 4-7 days of ICU stay. 40.6% patients had co-morbidities. Mortality was 62.9 %.

Conclusion: This study concludes that old age, HRCT score>15, need for mechanical ventilation, prolonged ICU stay, and presence of co-morbidities were associated with increased mortality among COVID-19 ICU-admitted patients.

Keywords: COVID-19, Mortality, Intensive care units, Mechanical Ventilation

https://doi.org/10.37939/jrmc.v30i1.2998

References

Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ et al. The origin, transmission, and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020 Mar 13;7(1):11. https://doi.org/10.1186/s40779-020-00240-0.

Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579(7798):265–269. https://doi.org/10.1038/s41586-020-2008-3.

Mahase E. Covid-19: WHO declares pandemic because of "alarming levels" of spread, severity, and inaction. BMJ. 2020;368:m1036. https://doi.org/10.1136/bmj.m1036.

Al Huraimel K, Alhosani M, Kunhabdulla S, Stietiya MH. SARS-CoV-2 in the environment: Modes of transmission, early detection and potential role of pollutions. Sci Total Environ. 2020;744:140946. https://doi.org/10.1016/j.scitotenv.2020.140946.

Sultana J, Mazzaglia G, Luxi N, Cancellieri A, Capuano A, Ferrajolo C et al. Potential effects of vaccinations on the prevention of COVID-19: rationale, clinical evidence, risks, and public health considerations. Expert Rev Vaccines. 2020 ;19(10):919-936. https://doi.org/10.1080/14760584.2020.1825951.

Rai P, Kumar BK, Deekshit VK, Karunasagar I, Karunasagar I. Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol. 2021;105(2):441-455. https://doi.org/10.1007/s00253-020-11061-5.

Asghar MS, Haider Kazmi SJ, Ahmed Khan N, Akram M, Ahmed Khan S, Rasheed U et al. Clinical profiles, characteristics, and outcomes of the first 100 admitted Covid-19 patients in Pakistan: A single-center retrospective study in a tertiary care hospital of Karachi. Cureus. 2020 Jun 20;12(6):e8712. https://doi.org/10.7759/cureus.c34.

Litton E, Bucci T, Chavan S, Ho YY, Holley A, Howard G et al. Surge capacity of intensive care units in case of acute increase in demand caused by COVID-19 in Australia. Med J Aust. 2020 ;212(10):463-467. https://doi.org/10.5694/mja2.50596.

Boussarsar M, Meddeb K, Toumi R, Ennouri E, Ayed S, Jarraya F et al. Resource utilization and preparedness within the COVID-19 pandemic in Tunisian medical intensive care units: A nationwide retrospective multicentre observational study. J Infect Public Health. 2023;16(5):727-735. https://doi.org/10.1016/j.jiph.2023.02.022.

Ayaz A, Arshad A, Malik H, Ali H, Hussain E, Jamil B. Risk factors for intensive care unit admission and mortality in hospitalized COVID-19 patients. Acute Crit Care. 2020 ;35(4):249-254. https://doi.org/10.4266/acc.2020.00381.

Akhtar H, Khalid S, Rahman FU, Umar M, Ali S, Afridi M et al. Presenting characteristics, comorbidities, and outcomes among patients with COVID-19 hospitalized in Pakistan: Retrospective observational study. JMIR Public Health Surveill. 2021;7(12):e32203. https://doi.org/10.2196/32203.

Nasir N, Habib K, Iffat Khanum, Khan N, Muhammad ZA, Mahmood SF. Clinical characteristics and outcomes of COVID-19: Experience at a major tertiary care center in Pakistan. J Infect Dev Ctries. 2021;15(4):480-489. https://doi.org/10.3855/jidc.14345.

Modi Asati A, Patel R, Singhal K, Jain C, Tripathi S. Clinical course and outcomes of COVID-19 patients admitted to the ICU of a tertiary care hospital in central India: A Cross-sectional study. Cureus. 2024;16(2):e54744. https://doi.org/10.7759/cureus.54744.

Fleuren LM, Dam TA, Tonutti M, de Bruin DP, Lalisang RCA, Gommers D et al. The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients. Crit Care. 2021;25(1):304. https://doi.org/10.1186/s13054-021-03733-z.

Zanella A, Florio G, Antonelli M, Bellani G, Berselli A, Bove T et al. Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units. Intensive Care Med. 2021;47(9):995-1008. https://doi.org/10.1007/s00134-021-06495-y.

Dennis JM, McGovern AP, Vollmer SJ, Mateen BA. Improving survival of critical care patients with coronavirus disease 2019 in England: A National Cohort Study, March to June 2020. Crit Care Med. 2021;49(2):209-214. https://doi.org/10.1097/CCM.0000000000004747.

Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy JAMA. 2020;323(16):1574-1581. https://doi.org/10.1001/jama.2020.5394.

Asfahan S, Deokar K, Dutt N, Niwas R, Jain P, Agarwal M. Extrapolation of mortality in COVID-19: Exploring the role of age, sex, co-morbidities and health-care related occupation. Monaldi Arch Chest Dis. 2020;90(2):313-317. https://doi.org/10.4081/monaldi.2020.1325.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3.

Larsson E, Brattström O, Agvald-Öhman C, Grip J, Campoccia Jalde F, Strålin K et al. Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden. Acta Anaesthesiol Scand. 2021;65(1):76-81. https://doi.org/10.1111/aas.13694.

Auld SC, Caridi-Scheible M, Blum JM, Robichaux C, Kraft C, Jacob JT et al. ICU and ventilator mortality among critically ill adults with Coronavirus disease 2019. Crit Care Med. 2020;48(9):e799-e804. https://doi.org/10.1097/CCM.0000000000004457.

Oliveira E, Parikh A, Lopez-Ruiz A, Carrilo M, Goldberg J, Cearras M et al. ICU outcomes and survival in patients with severe COVID-19 in the largest health care system in central Florida. PLoS One. 2021;16(3):e0249038. https://doi.org/10.1371/journal.pone.0249038.

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Copyright (c) 2026 Sehrish Asad, Muhammad Ali, Muhammad Salman, Ayesha Saeed